LONG-TERM EXPERIMENTAL EVOLUTION REVEALS PURIFYING SELECTION ON PIRNA-MEDIATED CONTROL OF TRANSPOSABLE ELEMENT EXPRESSION

Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression

Abstract Background Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes.In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transcription and thus restricting TE activity.Nevertheless, TE content varies widely across eukaryotes and the dynamics of TE a

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Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy.We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation.When anti-miR-124-treated mSOD1 MN (pr

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Diagnosis and treatment of anterior uveitis: optometric management

Jennifer S Harthan,1 Dominick L Opitz,2 Stephanie R Fromstein,1 Christina E Morettin3 1Cornea Center Beauty, Skincare and Health Care Products for Clinical Experience, 2Ophthalmology Services and Practice Development, 3Urgent Eye Care Service, Illinois College of Optometry, Chicago, IL, USA Abstract: Anterior uveitis encompasses inflammation of the

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